Textbook:

ESSENTIAL CELL BIOLOGY (4e)

ALBERTS • BRAY • HOPKIN • JOHNSON • LEWIS • RAFF • ROBERTS • WALTER

 

授課方式為立即學習、課後自學、新知解讀等。

 

經有效學習和效率學習，認識與應用細胞生物知識。

 

評分方式：課中習作(20%)、課後作業（20%）和二次考試（open book僅能帶課本，不可夾便條紙）各30%。

期刊試閲

請選擇以下任一期刊,以當週上課內容之keyword搜尋。請選一篇你有興趣的文章,以300字概述其重點,內容包括你為何選擇這篇論文。Sunday之前上傳該篇英文摘要和中文心得。

1.  Nature Cell Biology  http://www.nature.com/ncb/index.html

2.  Cell   http://www.cell.com/

3.  Molecular Cell  http://www.cell.com/molecular-cell/home

4.  Cell Death and Differentiation  http://www.nature.com/cdd/index.html

5.  The EMBO Journal  http://emboj.embopress.org/

6.  Journal of Cell Biology  http://jcb.rupress.org/

7.  Trends in Cell Biology  http://www.cell.com/trends/cell-biology/home

8.  Cell Reports  http://www.cell.com/cell-reports/home

9.  Molecular and Cellular Biology  http://mcb.asm.org/

 

班別：生科三A       學號：000888     姓名：唐世杰

Presynaptic Excitation via GABA_B Receptors in Habenula Cholinergic Neurons Regulates Fear Memory Expression

Cell Volume 166, Issue 3, p716–728, 28 July 2016

恐懼的記憶與GABA和鈣離子通道有關,有趣。

重點提示Highlights

•Habenula cholinergic neurons reduce fear memory expression

•Presynaptic GABAB activity of habenula neurons facilitates fear extinction

•GABAB drastically potentiates the corelease (co-release) of multiple neurotransmitters

•GABAB amplifies presynaptic Ca2+ entry through Cav2.3 channels

Fear behaviors are regulated by adaptive mechanisms that dampen their expression in the absence of danger. By studying circuits and the molecular mechanisms underlying this adaptive response, we show that cholinergic neurons of the medial habenula reduce fear memory expression through GABA_B presynaptic excitation. Ablating these neurons or inactivating their GABA_B receptors impairs fear extinction in mice, whereas activating the neurons or their axonal GABA_B receptors reduces conditioned fear. Although considered exclusively inhibitory, here, GABA_B mediates excitation by amplifying presynaptic Ca²⁺ entry through Ca_v2.3 channels and potentiating co-release of glutamate, acetylcholine, and neurokinin B to excite interpeduncular neurons. Activating the receptors for these neurotransmitters or enhancing neurotransmission with a phosphodiesterase inhibitor reduces fear responses of both wild-type and GABA_B mutant mice. We identify the role of an extra-amygdalar circuit and presynaptic GABA_B receptors in fear control, suggesting that boosting neurotransmission in this pathway might ameliorate some fear disorders.