[翰佳老師影音課程] 14-3 三種酵素催化的實例探討 - 生物化學 (二)

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長度: 42:52, 發表時間 : 2016-03-10 09:54

觀看次數 : 2,536

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1. Slide 1
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2. 14.5 What Can Be Learned From Typical Enzyme Mechanisms?
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3. Example 1: The Serine Proteases Family
02:34
4. zymogen
01:36
5. Catalytic Triad
01:57
6. Similarity of 3 Serine Proteases
01:00
7. The Catalytic Triad of the Serine Proteases
02:35
8. The substrate-binding pockets determine the substrate selectivity
00:26
9. Serine Protease Binding Pockets are Adapted to Particular Substrates
01:32
10. How to assay the activity of protease?
00:08
11. Serine Protease Binding Pockets are Adapted to Particular Substrates
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12. How to assay the activity of protease?
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13. Burst kinetics tell the mechanism of serine protease
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14. How to assay the activity of protease?
01:18
15. Burst kinetics tell the mechanism of serine protease
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16. Serine Protease Mechanism
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17. The Serine Protease Mechanism in Detail 1/5
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18. The Serine Protease Mechanism in Detail 2/5
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19. The Serine Protease Mechanism in Detail 3/5
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20. The Serine Protease Mechanism in Detail 4/5
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21. The Serine Protease Mechanism in Detail 5/5
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22. Transition-State Stabilization in the Serine Proteases
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23. The Serine Protease Mechanism in Detail 5/5
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24. The Serine Protease Mechanism in Detail 4/5
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25. The Serine Protease Mechanism in Detail 3/5
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26. The Serine Protease Mechanism in Detail 2/5
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27. The Serine Protease Mechanism in Detail 4/5
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28. Transition-State Stabilization in the Serine Proteases
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29. The “oxyanion hole”
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30. Example 2: The Aspartic Proteases
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31. Aspartic proteases play many roles in humans
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32. The Aspartic Proteases
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33. Aspartic Protease Mechanism
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34. A Mechanism for the Aspartic Proteases
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35. HIV-1 Protease
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36. Proteolytic cleavage pattern for the HIV genome
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37. Protease Inhibitors Block the Active Site of HIV-1 Protease
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38. Proteolytic cleavage pattern for the HIV genome
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39. Protease Inhibitors Block the Active Site of HIV-1 Protease
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40. Protease Inhibitors Give Life to AIDS Patients
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41. Protease Inhibitors Give Life to AIDS Patients
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42. Example 3: Chorismate Mutase
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43. Chorismate Mutase: A Model for Understanding Catalytic Power and Efficiency
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44. Chorismate Mutase: A Model for Understanding Catalytic Power and Efficiency
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45. Two possible mechanisms of chorismate rearrangement reaction
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46. Use TSA to understand the chair mechanism of chorismate mutase
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47. The structure of E. coli chorismate mutase
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48. The Chorismate Mutase Active Site Favors a NAC
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49. Slide 37
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50. Formation of a NAC is facile in the chorismate mutase active site
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51. To see is to believe!
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52. End of Part 3
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53. End of this class

長度: 42:52, 發表時間 : 2016-03-10 09:54

觀看次數 : 2,536

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