CH 24 - 生物化學 (二) | NTOU 易課平台

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長度: 2:36:24, 發表時間 : 2016-05-06 12:53

觀看次數 : 2,476

01:34
1. Slide 1
00:35
2. Focus on
00:36
3. Overview of Fatty Acid Metabolism
02:20
4. Synthesis of Fatty Acids: Production of malonyl-CoA is the initial and controlling step
00:04
5. Overview of Fatty Acid Metabolism
00:26
6. Synthesis of Fatty Acids: Production of malonyl-CoA is the initial and controlling step
01:27
7. Acetyl-CoA Carboxylase (ACC) Is Biotin-Dependent and Displays Ping-Pong Kinetics (In E. coli)
00:18
8. Synthesis of Fatty Acids: Production of malonyl-CoA is the initial and controlling step
00:47
9. Acetyl-CoA Carboxylase (ACC) Is Biotin-Dependent and Displays Ping-Pong Kinetics (In E. coli)
00:16
10. Quaternary structure of the E. coli BCCP (dimer)-BC(dimer) complex
00:04
11. Acetyl-CoA Carboxylase (ACC) Is Biotin-Dependent and Displays Ping-Pong Kinetics (In E. coli)
00:06
12. Quaternary structure of the E. coli BCCP (dimer)-BC(dimer) complex
00:53
13. Acetyl-CoA Carboxylase in Animals Is a Multifunctional Protein
02:26
14. The Activity of Acetyl-CoA Carboxylase Is Modulated by Phosphorylation and Dephosphorylation
02:04
15. Slide 9
02:48
16. Synthesis of Fatty Acids:
01:49
17. There are three principle sources of acetyl CoA:1.Amino acid degradation produces cytosolic acetyl CoA2.Fatty acid oxidation produces mitochondrial acetyl-CoA3.Glycolysis yields cytosolic pyruvate, which (after transport into the mitochondria) is conve
04:32
18. Slide 12
00:25
19. The citrate-malate-pyruvate shuttle
00:02
20. Slide 12
00:01
21. The citrate-malate-pyruvate shuttle
00:35
22. Slide 12
00:04
23. The citrate-malate-pyruvate shuttle
00:33
24. Fatty acid synthase
00:00
25. Slide 15
00:00
26. Fatty Acid Synthase (Fatty Acyl Synthase I) in Animal
00:00
27. (Fatty Acyl Synthase II; FAS II)
00:00
28. FAS II in yeast
00:03
29. Slide 19
00:00
30. FAS II in yeast
00:00
31. (Fatty Acyl Synthase II; FAS II)
00:00
32. Fatty Acid Synthase (Fatty Acyl Synthase I) in Animal
00:00
33. Slide 15
00:31
34. Fatty acid synthase
00:00
35. Slide 15
00:00
36. Fatty Acid Synthase (Fatty Acyl Synthase I) in Animal
00:50
37. (Fatty Acyl Synthase II; FAS II)
00:02
38. Fatty Acid Synthase (Fatty Acyl Synthase I) in Animal
00:00
39. Slide 15
00:23
40. Fatty acid synthase
00:00
41. Slide 15
00:59
42. Fatty Acid Synthase (Fatty Acyl Synthase I) in Animal
00:00
43. Slide 15
00:42
44. Fatty acid synthase
01:01
45. Slide 15
00:15
46. Fatty acid synthase
00:00
47. Slide 15
00:00
48. Fatty Acid Synthase (Fatty Acyl Synthase I) in Animal
00:29
49. (Fatty Acyl Synthase II; FAS II)
00:00
50. Fatty Acid Synthase (Fatty Acyl Synthase I) in Animal
00:00
51. Slide 15
00:00
52. Fatty Acid Synthase (Fatty Acyl Synthase I) in Animal
00:00
53. (Fatty Acyl Synthase II; FAS II)
00:14
54. FAS II in yeast
01:11
55. (Fatty Acyl Synthase II; FAS II)
00:02
56. Fatty Acid Synthase (Fatty Acyl Synthase I) in Animal
00:00
57. Slide 15
00:27
58. Fatty acid synthase
00:00
59. Slide 15
02:46
60. Fatty Acid Synthase (Fatty Acyl Synthase I) in Animal
00:05
61. Slide 15
00:01
62. Fatty Acid Synthase (Fatty Acyl Synthase I) in Animal
00:01
63. (Fatty Acyl Synthase II; FAS II)
00:00
64. FAS II in yeast
00:26
65. Slide 19
00:00
66. Slide 20
00:06
67. Slide 19
00:06
68. FAS II in yeast
00:05
69. Slide 19
00:01
70. Slide 20
00:34
71. Slide 21
00:00
72. Slide 20
00:00
73. Slide 19
00:00
74. FAS II in yeast
00:00
75. (Fatty Acyl Synthase II; FAS II)
00:13
76. Fatty Acid Synthase (Fatty Acyl Synthase I) in Animal
00:00
77. (Fatty Acyl Synthase II; FAS II)
00:00
78. FAS II in yeast
00:00
79. Slide 19
00:00
80. Slide 20
01:10
81. Slide 21
00:39
82. Slide 22
00:07
83. Slide 23
00:01
84. Slide 24
00:02
85. Slide 25
00:00
86. Slide 24
00:29
87. Slide 23
00:01
88. Slide 24
00:16
89. Slide 25
00:00
90. Slide 24
00:01
91. Slide 23
00:00
92. Slide 22
00:17
93. Slide 21
00:00
94. Slide 22
00:07
95. Slide 23
00:00
96. Slide 24
01:45
97. Slide 25
00:42
98. The Design Strategy for Fatty Acid Synthesis:Fatty acid chains are constructed by the addition of two-carbon units derived from acetyl-CoAThe acetate units are activated by carboxylation with CO2 to form malonyl-CoA (at the expense of ATP)The addition of
01:04
99. There Are Four Major Differences Between Fatty Acid Breakdown and Biosynthesis
00:00
100. The Design Strategy for Fatty Acid Synthesis:Fatty acid chains are constructed by the addition of two-carbon units derived from acetyl-CoAThe acetate units are activated by carboxylation with CO2 to form malonyl-CoA (at the expense of ATP)The addition of
00:00
101. Slide 25
00:00
102. Slide 24
00:00
103. Slide 23
00:00
104. Slide 22
00:00
105. Slide 21
00:12
106. Slide 20
00:00
107. Slide 21
00:00
108. Slide 22
00:00
109. Slide 23
00:00
110. Slide 24
00:00
111. Slide 25
00:01
112. The Design Strategy for Fatty Acid Synthesis:Fatty acid chains are constructed by the addition of two-carbon units derived from acetyl-CoAThe acetate units are activated by carboxylation with CO2 to form malonyl-CoA (at the expense of ATP)The addition of
03:05
113. There Are Four Major Differences Between Fatty Acid Breakdown and Biosynthesis
00:45
114. Slide 28
02:23
115. C16 Fatty Acids May Undergo Elongation and Unsaturation
04:35
116. Slide 30
00:10
117. Elongation of Fatty Acids in Endoplasmic Reticulum
00:00
118. Slide 30
00:00
119. C16 Fatty Acids May Undergo Elongation and Unsaturation
00:10
120. Slide 28
00:00
121. C16 Fatty Acids May Undergo Elongation and Unsaturation
00:00
122. Slide 30
00:13
123. Elongation of Fatty Acids in Endoplasmic Reticulum
00:05
124. Elongation of Fatty Acids in Mitochondria Is Initiated by the Thiolase Reaction
00:09
125. Elongation of Fatty Acids in Endoplasmic Reticulum
00:39
126. Elongation of Fatty Acids in Mitochondria Is Initiated by the Thiolase Reaction
00:18
127. Elongation of Fatty Acids in Endoplasmic Reticulum
00:20
128. Elongation of Fatty Acids in Mitochondria Is Initiated by the Thiolase Reaction
01:39
129. Unsaturation Reactions Occur in Eukaryotesin the Middle of an Aliphatic Chain
00:01
130. Slide 34
00:22
131. Unsaturation Reactions Occur in Eukaryotesin the Middle of an Aliphatic Chain
00:04
132. Slide 34
00:00
133. Slide 35
05:38
134. Slide 34
02:03
135. Slide 35
00:31
136. Mammals Cannot Synthesize Most Polyunsaturated Fatty Acids
00:06
137. Slide 1
00:00
138. Focus on
00:00
139. Overview of Fatty Acid Metabolism
00:00
140. Synthesis of Fatty Acids: Production of malonyl-CoA is the initial and controlling step
00:00
141. Acetyl-CoA Carboxylase (ACC) Is Biotin-Dependent and Displays Ping-Pong Kinetics (In E. coli)
00:01
142. Quaternary structure of the E. coli BCCP (dimer)-BC(dimer) complex
00:00
143. Acetyl-CoA Carboxylase in Animals Is a Multifunctional Protein
00:00
144. The Activity of Acetyl-CoA Carboxylase Is Modulated by Phosphorylation and Dephosphorylation
00:00
145. Slide 9
00:00
146. Synthesis of Fatty Acids:
00:00
147. There are three principle sources of acetyl CoA:1.Amino acid degradation produces cytosolic acetyl CoA2.Fatty acid oxidation produces mitochondrial acetyl-CoA3.Glycolysis yields cytosolic pyruvate, which (after transport into the mitochondria) is conve
00:00
148. Slide 12
00:00
149. The citrate-malate-pyruvate shuttle
00:00
150. Fatty acid synthase
00:00
151. Slide 15
00:00
152. Fatty Acid Synthase (Fatty Acyl Synthase I) in Animal
00:00
153. (Fatty Acyl Synthase II; FAS II)
00:00
154. FAS II in yeast
00:07
155. Slide 19
00:02
156. Slide 20
00:00
157. Slide 19
00:00
158. FAS II in yeast
00:00
159. Slide 19
00:00
160. FAS II in yeast
00:00
161. Slide 19
00:00
162. FAS II in yeast
00:00
163. Slide 19
00:00
164. FAS II in yeast
00:00
165. Slide 19
00:00
166. FAS II in yeast
00:00
167. (Fatty Acyl Synthase II; FAS II)
00:00
168. Fatty Acid Synthase (Fatty Acyl Synthase I) in Animal
00:00
169. Slide 15
00:00
170. Fatty acid synthase
00:00
171. The citrate-malate-pyruvate shuttle
00:00
172. Slide 12
00:00
173. There are three principle sources of acetyl CoA:1.Amino acid degradation produces cytosolic acetyl CoA2.Fatty acid oxidation produces mitochondrial acetyl-CoA3.Glycolysis yields cytosolic pyruvate, which (after transport into the mitochondria) is conve
00:00
174. Synthesis of Fatty Acids:
00:00
175. Slide 9
00:00
176. The Activity of Acetyl-CoA Carboxylase Is Modulated by Phosphorylation and Dephosphorylation
00:01
177. Acetyl-CoA Carboxylase in Animals Is a Multifunctional Protein
00:00
178. Quaternary structure of the E. coli BCCP (dimer)-BC(dimer) complex
00:00
179. Acetyl-CoA Carboxylase (ACC) Is Biotin-Dependent and Displays Ping-Pong Kinetics (In E. coli)
01:09
180. Synthesis of Fatty Acids: Production of malonyl-CoA is the initial and controlling step
00:00
181. Overview of Fatty Acid Metabolism
00:00
182. Focus on
01:41
183. Overview of Fatty Acid Metabolism
00:07
184. Synthesis of Fatty Acids: Production of malonyl-CoA is the initial and controlling step
00:00
185. Acetyl-CoA Carboxylase (ACC) Is Biotin-Dependent and Displays Ping-Pong Kinetics (In E. coli)
00:00
186. Quaternary structure of the E. coli BCCP (dimer)-BC(dimer) complex
00:00
187. Acetyl-CoA Carboxylase in Animals Is a Multifunctional Protein
00:00
188. The Activity of Acetyl-CoA Carboxylase Is Modulated by Phosphorylation and Dephosphorylation
00:00
189. Slide 9
00:00
190. Synthesis of Fatty Acids:
00:00
191. There are three principle sources of acetyl CoA:1.Amino acid degradation produces cytosolic acetyl CoA2.Fatty acid oxidation produces mitochondrial acetyl-CoA3.Glycolysis yields cytosolic pyruvate, which (after transport into the mitochondria) is conve
00:17
192. Slide 12
00:00
193. The citrate-malate-pyruvate shuttle
00:03
194. Fatty acid synthase
00:00
195. Slide 15
01:07
196. Fatty Acid Synthase (Fatty Acyl Synthase I) in Animal
00:00
197. Slide 15
00:02
198. Fatty acid synthase
00:01
199. The citrate-malate-pyruvate shuttle
01:47
200. Slide 12
00:00
201. The citrate-malate-pyruvate shuttle
00:00
202. Fatty acid synthase
00:00
203. Slide 15
00:00
204. Fatty Acid Synthase (Fatty Acyl Synthase I) in Animal
00:01
205. (Fatty Acyl Synthase II; FAS II)
00:01
206. FAS II in yeast
00:00
207. Slide 19
00:00
208. Slide 20
00:00
209. Slide 21
00:00
210. Slide 22
00:00
211. Slide 23
00:00
212. Slide 24
00:00
213. Slide 25
00:00
214. The Design Strategy for Fatty Acid Synthesis:Fatty acid chains are constructed by the addition of two-carbon units derived from acetyl-CoAThe acetate units are activated by carboxylation with CO2 to form malonyl-CoA (at the expense of ATP)The addition of
00:00
215. There Are Four Major Differences Between Fatty Acid Breakdown and Biosynthesis
00:00
216. Slide 28
00:00
217. C16 Fatty Acids May Undergo Elongation and Unsaturation
00:00
218. Slide 30
00:01
219. Elongation of Fatty Acids in Endoplasmic Reticulum
00:00
220. Elongation of Fatty Acids in Mitochondria Is Initiated by the Thiolase Reaction
00:01
221. Unsaturation Reactions Occur in Eukaryotesin the Middle of an Aliphatic Chain
00:00
222. Slide 34
00:00
223. Slide 35
00:46
224. Mammals Cannot Synthesize Most Polyunsaturated Fatty Acids
02:20
225. Mammals Cannot Synthesize Most Polyunsaturated Fatty Acids
00:55
226. Arachidonic Acid (ω6; 20:4) Is Synthesized from Linoleic AcidBy Mammals
00:28
227. Arachidonic Acid (ω6 ; 20:4) Is Synthesized from Linoleic AcidBy Mammals
08:09
228. ω3 and ω6 – Essential Fatty Acids with Many Functions
00:00
229. ω3 and ω6─Essential Fatty Acids with Many Functions
00:00
230. ω3 and ω6 – Essential Fatty Acids with Many Functions
00:01
231. Arachidonic Acid (ω6 ; 20:4) Is Synthesized from Linoleic AcidBy Mammals
00:00
232. ω3 and ω6 – Essential Fatty Acids with Many Functions
00:00
233. ω3 and ω6─Essential Fatty Acids with Many Functions
00:00
234. Regulation of Fatty Acid Synthesis and Fatty Acid Oxidation
00:00
235. How Are Complex Lipids Synthesized?
00:00
236. Regulation of Fatty Acid Synthesis and Fatty Acid Oxidation
00:00
237. ω3 and ω6─Essential Fatty Acids with Many Functions
00:00
238. ω3 and ω6 – Essential Fatty Acids with Many Functions
00:00
239. Arachidonic Acid (ω6 ; 20:4) Is Synthesized from Linoleic AcidBy Mammals
00:00
240. Arachidonic Acid (ω6; 20:4) Is Synthesized from Linoleic AcidBy Mammals
00:00
241. Mammals Cannot Synthesize Most Polyunsaturated Fatty Acids
00:00
242. Slide 35
00:00
243. Slide 34
00:00
244. Unsaturation Reactions Occur in Eukaryotesin the Middle of an Aliphatic Chain
00:00
245. Elongation of Fatty Acids in Mitochondria Is Initiated by the Thiolase Reaction
00:00
246. Elongation of Fatty Acids in Endoplasmic Reticulum
00:00
247. Elongation of Fatty Acids in Mitochondria Is Initiated by the Thiolase Reaction
00:00
248. Unsaturation Reactions Occur in Eukaryotesin the Middle of an Aliphatic Chain
00:00
249. Slide 34
00:01
250. Slide 35
00:00
251. Mammals Cannot Synthesize Most Polyunsaturated Fatty Acids
00:00
252. Arachidonic Acid (ω6; 20:4) Is Synthesized from Linoleic AcidBy Mammals
00:00
253. Arachidonic Acid (ω6 ; 20:4) Is Synthesized from Linoleic AcidBy Mammals
01:16
254. ω3 and ω6 – Essential Fatty Acids with Many Functions
01:10
255. ω3 and ω6─Essential Fatty Acids with Many Functions
04:32
256. Regulation of Fatty Acid Synthesis and Fatty Acid Oxidation
00:05
257. How Are Complex Lipids Synthesized?
01:51
258. Lipids Synthesis
02:57
259. How Are Complex Lipids Synthesized?
02:36
260. Page 808
01:22
261. How Are Complex Lipids Synthesized?
00:00
262. Page 808
00:26
263. Slide 46
00:00
264. Page 808
00:12
265. How Are Complex Lipids Synthesized?
00:00
266. Page 808
00:28
267. Slide 46
00:00
268. Page 808
00:25
269. How Are Complex Lipids Synthesized?
00:01
270. Page 808
00:02
271. Slide 46
00:03
272. Page 808
00:02
273. Slide 46
00:15
274. Page 808
00:57
275. Slide 46
00:20
276. Page 808
00:12
277. Slide 46
01:01
278. Page 808
00:50
279. Page 808
00:00
280. Page 808
00:07
281. Slide 46
00:00
282. Page 808
00:38
283. Page 808
02:27
284. Page 810
00:01
285. Page 808
00:00
286. Page 810
00:01
287. Lipins – Phosphatases Essential for Triglyceride Synthesis and Other Functions (New in 6th edition, 2017)
00:00
288. Lipins – Phosphatases Essential for Triglyceride Synthesis and Other Functions(New in 6th edition, 2017)
00:34
289. Page 812
00:34
290. Page 811
00:00
291. Page 812
00:00
292. Lipins – Phosphatases Essential for Triglyceride Synthesis and Other Functions(New in 6th edition, 2017)
00:00
293. Lipins – Phosphatases Essential for Triglyceride Synthesis and Other Functions (New in 6th edition, 2017)
00:21
294. Page 810
00:00
295. Lipins – Phosphatases Essential for Triglyceride Synthesis and Other Functions (New in 6th edition, 2017)
00:00
296. Lipins – Phosphatases Essential for Triglyceride Synthesis and Other Functions(New in 6th edition, 2017)
00:00
297. Page 812
03:50
298. Page 811
00:00
299. Ether glycerophospholipids: plasmalogen & PAF
00:01
300. Page 811
00:00
301. Page 812
00:00
302. Lipins – Phosphatases Essential for Triglyceride Synthesis and Other Functions(New in 6th edition, 2017)
03:35
303. Lipins – Phosphatases Essential for Triglyceride Synthesis and Other Functions (New in 6th edition, 2017)
00:32
304. Lipins – Phosphatases Essential for Triglyceride Synthesis and Other Functions(New in 6th edition, 2017)
00:00
305. Lipins – Phosphatases Essential for Triglyceride Synthesis and Other Functions (New in 6th edition, 2017)
00:25
306. Page 810
02:02
307. Lipins – Phosphatases Essential for Triglyceride Synthesis and Other Functions (New in 6th edition, 2017)
00:01
308. Lipins – Phosphatases Essential for Triglyceride Synthesis and Other Functions(New in 6th edition, 2017)
00:00
309. Page 812
00:00
310. Page 811
00:56
311. Ether glycerophospholipids: plasmalogen & PAF
00:02
312. Page 813
00:31
313. Ether glycerophospholipids: plasmalogen & PAF
00:17
314. Page 813
00:54
315. Page 813 & 814
00:12
316. Page 814
00:19
317. Page 813 & 814
00:01
318. Page 814
00:03
319. Slide 58
02:43
320. Slide 59
00:21
321. Slide 60
00:30
322. Slide 61
00:00
323. Slide 60
00:01
324. Slide 61
00:09
325. Page 815
00:00
326. Slide 61
00:00
327. Slide 60
00:11
328. Slide 59
00:00
329. Slide 60
00:00
330. Slide 61
00:34
331. Page 815
00:00
332. Slide 61
00:00
333. Slide 60
00:48
334. Slide 59
00:00
335. Slide 60
00:00
336. Slide 61
00:13
337. Page 815
02:38
338. Page 816
01:12
339. How Are Eicosanoids Synthesized, and What Are Their Functions?
00:00
340. How Are Eicosanoids Synthesized, and What Are Their Functions?
00:50
341. Page 818
00:01
342. How Are Eicosanoids Synthesized, and What Are Their Functions?
00:02
343. How Are Eicosanoids Synthesized, and What Are Their Functions?
00:00
344. How Are Eicosanoids Synthesized, and What Are Their Functions?
00:00
345. Page 818
00:00
346. Page 818
01:58
347. Prostaglandins Are Formed from Arachidonate by Oxidation and Cyclization
00:00
348. Page 818
00:26
349. Page 818
00:01
350. How Are Eicosanoids Synthesized, and What Are Their Functions?
00:43
351. How Are Eicosanoids Synthesized, and What Are Their Functions?
00:00
352. How Are Eicosanoids Synthesized, and What Are Their Functions?
00:00
353. Page 818
02:57
354. Page 818
00:01
355. Page 818
00:00
356. How Are Eicosanoids Synthesized, and What Are Their Functions?
00:15
357. How Are Eicosanoids Synthesized, and What Are Their Functions?
00:00
358. How Are Eicosanoids Synthesized, and What Are Their Functions?
00:00
359. Page 818
00:00
360. Page 818
00:31
361. Prostaglandins Are Formed from Arachidonate by Oxidation and Cyclization
00:00
362. Page 818
00:00
363. Page 818
00:00
364. How Are Eicosanoids Synthesized, and What Are Their Functions?
00:42
365. How Are Eicosanoids Synthesized, and What Are Their Functions?
01:31
366. How Are Eicosanoids Synthesized, and What Are Their Functions?
00:00
367. Page 818
00:00
368. Page 818
00:01
369. Prostaglandins Are Formed from Arachidonate by Oxidation and Cyclization
00:04
370. Eicosanoids
03:12
371. Prostaglandin
02:29
372. Lipoxins – Anti-Inflammatory Eicosanoid Products of Transcellular Metabolism (New in 6th edition, 2017)
00:36
373. Lipoxins – Anti-Inflammatory Eicosanoid Products of Transcellular Metabolism
00:05
374. Aspirin and Other NSAIDs (Nonsteroidal Anti-inflammatory Drugs) Block Synthesis of Prostaglandins
00:02
375. The Molecular Basis for the Action of Nonsteroidal Anti-Inflammatory Drugs
02:09
376. Aspirin and Other NSAIDs (Nonsteroidal Anti-inflammatory Drugs) Block Synthesis of Prostaglandins
00:03
377. The Molecular Basis for the Action of Nonsteroidal Anti-Inflammatory Drugs
00:00
378. Why Do the New “COX-2 Inhibitors” Bind to (and Inhibit)COX-2 But Not COX-1?

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2016 CH24 Lipid biosynthesis

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