發表時間 : 2015-12-11 12:32
觀看次數 : 3,376
附件
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依璇
活化 eukaryotic transcription:
- relief from the repression imposed by chromatin structure
- Chromatin-remodeling complexes: mediate ATP-dependent conformational changes in nucleosome structure
- histone-modifying enzymes: introduce covalent modifications into the N-terminal tails of the histone core octamer.
(1) HAT (histone acetyltransferases)
- ubiquitination
- sumoylation
- acetylation
- deacetylation: HDAC (histone deacetylase complexes) catalyze the removal of acetyl groups from lysine residues along the histone tails, restoring the chromatin to a repressed state.
- methylation
依璇
Mediator as arepressor.
- If mediator interacts with a co-repressor bound to a silencer and then binds the repressive subcomplex (MED12: MED13: CycC:CDK8), shown in pink here, it fails to recruit RNA polymerase II and the GTFs to the promoter, and expression from the promoter is repressed
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